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Abstract

EVALUATION OF THE WOUND HEALING ACTIVITY OF A NOVEL ALOE HYDROGEL IN ALBINO RATS

Priti Tagde*, Nidhi Patel and Jagdish Rathi

ABSTRACT

This paper describes a methodology to produce films composed of carbopol and Aloe vera gel were prepared and characterized for application in the treatment of several types of wounds. The in -vivo study of aloe hydrogel was performed on albino rats using excision wound model and it was found that the formulation has heal the wound in 16 days which was almost equal to standard ointment. The present research work accomplished the combination of anti-bacterial therapy and a healing promoting moisturization. It involved formulation of a new topical herbal hydrogel allowing for both antiseptic and moist wound healing for treatment and it also provide cooling sensation. Results show a positive influence of Aloe vera on the transparency of the films, in both dry and wet state. Films were immersed in acetate buffer at pH 5.5 simulating the value of the skin, to evaluate its water absorption capacity. It was found that water absorption increases as the Aloe vera content increases, suggesting that Aloe vera enhances the hydrophilic properties of the films. Aloe Hydrogel was found to have better and faster wound healing effect than standard drug Povidone Iodine ointment on excision wound model.

Keywords: Wound healing, Excision wound, Hydrogel & Wound closure.


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