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Abstract

EVALUATION OF HEPATOPROTECTIVE EFFECT OF PSEUDARTHRIA VISCIDA LINN AGAINST DMBA INDUCED LIVER DAMAGE IN WISTAR RATS

Vijaya Baskaran Manickam*, Gomathi Swaminathan and Sambathkumar Ramanathan

ABSTRACT

The whole plant of Pesudarthria viscida Linn is used for the treatment of various hepatic disorders. In the present study, the effect of ethanolic extract of Pesudarthria viscida Linn (EEPV) on 7,12- dimethyl benz[α]anthracene (DMBA) induced liver damage in Wistar albino rats were studied. A daily dose of 100 mg/kg and 200 mg/kg of the extract was administered to the experimental animals for 90 days. After the induction of the tumour the treatment period was started and continued up to 150 days. The results showed that significant hepatoprotective effect (P<0.01and P<0.001) was achieved against DMBA induced liver damage, by oral administration of EEPV as evident from decreased levels of serum enzymes in the treated groups, compared to that of control. The hepatoprotective activity was also supported by histopathological studies of liver tissue. Thus the present study provides a scientific foundation for the traditional usage of this plant in the management of liver diseases.

Keywords: Pesudarthria viscida, DMBA, hepatoprotective activity, histopathological studies.


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