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Abstract

ROLE OF ULTRA-DILUTED BELLADONNA EXTRACT IN THE IMMUNE MEDIATED HEALING OF JE VIRUS INFECTION IN MICE

Bhaswati Bandyopadhyay*, Arup Banerjee, Satadal Das, Milan Sengupta, Rathin Chakravarty and Krishnangshu Ray

ABSTRACT

Japanese encephalitis (JE) is highly prevalent in South East Asian countries, and is gradually spreading in adjoining countries, as there is a great obscurity in preventing the disease by vaccines, due to lack of adequate accessibility to remote places in the endemic region of developing countries. There are evidences that “Belladonna 200” –an ultra diluted homeopathic medicine, is capable of prevention, as well as remission of JE in mice. Such encouraging result prompted us to investigate, whether there is any role of this alternative medicine in immune alleviation of JE, in Webster strain of Swiss albino mice model, induced by virulent Nakayama strain of JE virus. RNA was extracted from brain tissue of JE infected mice (controls), and “Belladonna 200” treated JE infected mice (experimental group), followed by estimation of JE viral load, and relative mRNA expressions of CCR-5, IFN-β, TLR-3, TLR-7, IL-6, TNF α, ISG 15, MX1 and IFIT1 by real time PCR, and the results were compared and analyzed, between the experimental group and the control group. In the experimental group five out of six mice did not show any sign of sickness till 6th day post inoculation of JE virus; while in the control group the inoculated mice developed signs of sickness from the 3rd day, and death occurred in three of six inoculated mice by 5th-6th post inoculation day. The results revealed that there was a considerable decrease of JE viral load, along with marked increase in relative mRNA expressions of IFN-β, MX1, and CCR-5, in “Belladonna 200” treated mice, compared to the control group; while there was no change in TLR-3 and TNF levels. Thus these findings indicate an explicit role of “Belladonna 200” in immune activated mitigation of JE.

Keywords: Japanese encephalitis, Belladonna 200, CCR-5, IFN-?, TLR-3, TLR-7, IL- 6,TNF, ISG 15, MX1 and IFIT1 .


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