THE ANTI-ULCEROGENIC ACTIVITY OF THE CRUDE METHANOLIC EXTRACT OF MONECHMA CILIATUM SEEDS
*Amna Elhassan Hamad Mohammad, Sania Abdallah Shaddad, Osama Yosuf
Mohamed and Ahmed Mohamed Ibrahim Hamad
ABSTRACT
This study was carried out to evaluate the anti-ulcerogenic activity of
the methanolic extract of Monechma ciliatum seeds to validate its
traditional uses in treatment of stomach disturbances. The methanolic
extract of Monechma ciliatum seeds was screened for its antiulcerogenic
activity against induced-ulcer in four different models. The
phytochemical screening of the plant showed that flavonoids, sterols,
alkaloids, triterpenes, tannins and saponins are the main constituents of
the plant. The results showed that the methanolic extract of Monechma
ciliatum seeds at a dose 300mg/kg markedly decreased the incidence of
ulcer induced by oral administration of ethanolic HCl in mice by
81.86% ulcer inhibition where as sucralfate showed 50.54% ulcer
inhibition, as well as it significantly inhibited ulcer induced by water
immersion stress in rats by 86.92%ulcer inhibition, whereas
omeprazole showed 100% ulcer inhibition. Also the extract reduced
ulcer index compared with the control (10.66±0.53 – 14.72±0.65) in
aspirin-induced ulcer. At a dose 400μg/ml the extract elevated stomach
pH{H+} to (0.0015) compared with pH {H+} (0.0050) induced by histamine( 2 μg/ml). The
results obtained from this study revealed that the methanolic extract of M.ciliatum seeds
possesses anti-ulcerogenic activity.
Keywords: Anti-ulcer, Monechma ciliatum, Water immersion stress induced ulcer.
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