Abstract

THE ANTI-ULCEROGENIC ACTIVITY OF THE CRUDE METHANOLIC EXTRACT OF MONECHMA CILIATUM SEEDS

*Amna Elhassan Hamad Mohammad, Sania Abdallah Shaddad, Osama Yosuf
Mohamed and Ahmed Mohamed Ibrahim Hamad

ABSTRACT

This study was carried out to evaluate the anti-ulcerogenic activity of the methanolic extract of Monechma ciliatum seeds to validate its traditional uses in treatment of stomach disturbances. The methanolic extract of Monechma ciliatum seeds was screened for its antiulcerogenic activity against induced-ulcer in four different models. The phytochemical screening of the plant showed that flavonoids, sterols, alkaloids, triterpenes, tannins and saponins are the main constituents of the plant. The results showed that the methanolic extract of Monechma ciliatum seeds at a dose 300mg/kg markedly decreased the incidence of ulcer induced by oral administration of ethanolic HCl in mice by 81.86% ulcer inhibition where as sucralfate showed 50.54% ulcer inhibition, as well as it significantly inhibited ulcer induced by water immersion stress in rats by 86.92%ulcer inhibition, whereas omeprazole showed 100% ulcer inhibition. Also the extract reduced ulcer index compared with the control (10.66±0.53 – 14.72±0.65) in aspirin-induced ulcer. At a dose 400μg/ml the extract elevated stomach pH{H+} to (0.0015) compared with pH {H+} (0.0050) induced by histamine( 2 μg/ml). The results obtained from this study revealed that the methanolic extract of M.ciliatum seeds possesses anti-ulcerogenic activity.

Keywords: Anti-ulcer, Monechma ciliatum, Water immersion stress induced ulcer.