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Abstract

SAR: SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NOVEL 5-(2-FLUORO / 2, 3-DI FLUORO PHENYL) - 1, 3, 4-THIADIAZOLE-2- AMINE DERIVATVES AS ANTI-CANCER COMPOUNDS

Sushama S. Kadam*, Dr. G. M. Nazeruddin, M. Rafique Sarkhwas and S. B. Suryawanshi

ABSTRACT

Structure-activity relationships (SAR) are the traditional practices of
medicinal chemistry, which try to modify the effect or the potency (i.e.
activity) of bioactive chemical compounds by modifying their
chemical structure. Medicinal chemists use the techniques of chemical
synthesis to insert new chemical groups into the biomedical compound
and test the modifications for their biological effects. The 5(2, 4-
dihydroxy phenyl) 1, 3, 4, thiadiazole-2-amine’s set are well known
compounds with interesting in vitro and in vivo anti-cancer profiles.
On the basis of SAR we wish to report here with synthesis of eight
novel 5-(2-fluoro and 2, 3-difluoro phenyl)-1, 3, 4-thiadiazole-2-amine
and their derivatives.They are evaluated for anti-microbial activity
They may have potential anti-cancer activity.

Keywords: Structure-activity relationships (SAR), 1, 3, 4, Thiadiazole derivatives,Anti-microbial activity, Anti-cancer activity


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