WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

RECENT AND PRODUCTIVE VAGINAL IRRITATION TESTS FOR MICROBICIDAL BIOADHESIVE GELS IN NEW ZEALAND STAT FEMALE RABBITS

Mahesh Ramrao Sherkar*, Ashok Vitthal Bhosale and Vaishali R. Undale

ABSTRACT

Rabbits are highly sensitive to vaginal irritant than human. International Organization for Standardization (ISO) protocol 10993- 10 was used, for in vivo Rabbit Vaginal Irritation (RVI) test. Twelve healthy, non pregnant, non lactating New Zealand stat female rabbits were taken and four groups of equal animals were made. 1ml of blank and test samples (1% Microbicides (Abacavir sulfate, didanosine carbonate, and tenofovir disoproxil fumarate) loaded nanoparticles of chitosan-polyethylene oxide-polypropylene oxide dispersed 1% HPMC intra vaginal gel formulations) were tested for twice a day for three days on external genitalia, and intra-vaginal tissues. Fourth day was wash out period, and same procedure was repeated for carbopol gel. All animals were evaluated for epithelial ulceration, vascular congestion, swelling, edema, redness, erythrema, vaginal tolerance, and safety of formulations. All rabbits showed no signs of swelling, redness, erythrema, edema, epithelial ulceration, and vascular congestion of vaginal tissues safety of the developed formulations. These Studies were carried out at PDEA’s Seth Govind Raghunath Sable College of Pharmacy, Saswad, India.

Keywords: Gel, irritation, microbicide, nanoparticle, rabbit, vagina.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More