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Abstract

IN VIVO BIODISTRIBUTION AND PHOTOTHERMAL PROPERTIES OF Fe3O4 MAGNETIC NANOPARTICLE: EFFECT OF DIFFERENT SIZE

Khalid M. Gadora*, Danhua Huang, Bashir A. Yousef and Shen Song

ABSTRACT

Magnetic nanoparticles [MNPs] have unique features; especially the size which allows us to develop a new approach for different medical applications. Thus, the aims of this study were to develop and characterize the Fe3O4 nanoparticles (NPs), in order to study the effect of different particle size on their properties. The monodisperse watersoluble magnetite (Fe3O4) nanoparticles were synthesized by hydrothermal method, in which two polyols: ethylene glycol (EG) and diethylene glycol (DEG) were chosen to act as solvent and reductant. The size and morphology of products were characterized by transmission electron microscopy (TEM); magnetic property was studied with a magnet; in vitro photothermal effect was investigated by semiconductor laser; in vivo biodistribution was measured using mice injected with Indocyanine green (ICG) at different time points. Results showed that monodisperse watersoluble Fe3O4 NPs with different sizes and uniform shape were prepared successfully. Furthermore, the products exhibited decent magnetic properties at room temperature. Besides, Fe3O4 NPs demonstrated good photosensitizing features due to its photothermal properties. In vivo Fe3O4 NPs accumulated in the tumor tissue, and different sizes of Fe3O4 NPs had different accumulation rates. Finally, our findings revealed that the synthesized Fe3O4 NPs could be used in different medical aspects especially in drug delivery technology and magnetic resonance imaging for cancer therapy.

Keywords: Fe3O4 nanoparticles; magnetic properties; photothermal; particle size; biodistribution.


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