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Abstract

PROGNOSIS, RESPONSE TO TREATMENT OF HIGH RISK GTN DISEASE DUE TO POSSIBLE RISK FACTOR: IS BLOOD TYPE EFFECTIVE ON RESPONSE TO THE TREATMENT?

Fatemeh Cheraghi and *Khatereh Hekmatnia

ABSTRACT

Introduction: Gestational trophoblastic disease or GTD includes a diverse group of neoblastic disorders that arise from epithelial trophoblastic of placenta and is characterized by high levels of blood βHCG. Researchers are trying to find more information about the markers associated with this disease to find better prognosis and a greater understanding of the disease. One of the markers focused by researchers in various fields of medical science is the blood type. In this research we studied high risk GTN patients (gestational trophoblastic neoplasia) with the aim of surveying prevalence of the disease based on blood type. Method: In a cross-sectional study of descriptive analysis with the aim of determining the effect of blood type on prevalence of high risk GTN disease and also its effect on the response to treatment, 160 patients and case files were examined, 37 cases of which were excluded due to factors such as lack ofcooperation and missing documents. Then a questionnaire consisting of patient's demographic data, blood type, type of GTD and the patient's response to treatment was prepared, and the information were recorded in questionnaires and analyzed for selected patients. Results: Blood types of patients were often O and A. 69 people had blood group A who constitute 56.1%. The number of people with O blood group was 33 who constituted 26.8%. 21 people with blood type B/AB constituted 17.1%. The chance of treatment response showed no significant difference in any of the various blood groups (P> 0.05). Conclusion: Gestational trophoblastic disease is more common in patients with blood types A and O but the chance of treatment response in these patients was not significantly associated with blood type, of course, to cite more accurate results, more research is needed in different societies.

Keywords: gestational trophoblastic disease (GTD), blood groups (types) ABO, ?HCG.


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