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Abstract

COMPARATIVE ASSESSMENT OF THE QUALITY OF SOME COMMERCIAL BRANDS OF ARTESUNATE AND AMODIAQUINE ANTIMALARIAL COMBINATION DRUGS IN THE NIGERIAN MARKET

*Uzondu Akueyinwa Lovet Esther and Okafo Sinodukoo Eziuzo

ABSTRACT

In Nigeria, the increase in demand for artemisinin based combination therapy especially the artesunate and amodiaquine combination has lead to the proliferation of different brands for sale of which some are suspected to be counterfeit or substandard. Therefore, this work was undertaken to assess the quality of some artesunate and amodiaquine combination brands sold in Nigeria using HPLC. Three fixed - doses and one co – blistered brands of artesunate were assessed using uniformity of weight, disintegration time, tensile stregnth and friability tests. H.P.L.C. was used to determine the percentage artesunate and amodiaquine content of the tablets. Results showed that crushing strength (N) ranged from 4.49 ± 1.37 to 13.70 ± 4.56 kgf. Friability ranged from 0.001 to 0.800 and disintegration time was from 28.28 ± 4.62 to 92.65 ± 23.37. For weight uniformity test, none deviated by up to 5% which was satisfactory. The retention time for amodiaquine and artesunate were 4.2 min and 6.2 min respectively. The percentage concentration of amodiaquine in batches A, B, C, and D1 were 98, 98, 99 and 98.5% respectively while the percentage artesunate concentration was 97, 98, 98 and 99% for batches A, B, C and D2 respectively. The result showed that the products passed the tests. Having met the pharmacopoeia recommendations, the products were confirmed not to be substandard.

Keywords: Comparative assessment, artesunate/amodiaquine combinations, Nigerian market.


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