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Abstract

THE FUNCTIONAL TH1-TH2 PARADIGM AMONG MULTIGRAVIDA WOMEN USING CONTRACEPTIVES

Ibrahim Mohamed Saeed Shnawa*, Lubna AA Al Byatte and A. K. Alseraj

ABSTRACT

The functional TH1-TH2 paradigm are being investigated in multigravida women using three different contraceptive modalities as compared to non-contraceptive using mutigravida women control and virgin control. Five groups each of ten women were elected. First was pill user, second use injection, third use intrauterine device, fourth was non-cnotraceptive using mutigravida control and the fifth was the virgin control. Interferon gamma and inter-leukine 6 were the functional representatives of TH1 and TH2 respectively. Health status, subject history and blood sampling were performed by the gynecologist of the team. Five mili-liters of blood without anticoagulant were collected from the test and control women. Sera were separated and saved at -18C till cytokine determination once using eliza INFg and IL6 kets and readings were made using eliza equipment. The herd cytokine response in both INFg and IL6 were being in three categories, the low, the moderate and the high responders. While the cytokine response plots were of Gaussian distribution curve types. The fourth and fifth control groups were showing 70% TH1-TH2 balance and 30% TH1 polarity respectively. Pill using were expressing 50% TH1 polarity, 20% TH2 polarity and 30% TH1-TH2 balance. While injection using group has shown has shown 50% TH1 polarity and 50% TH1-TH2 balance. Intrauterine device users have shown 60% Th1 polarity and 40% TH1-TH2 balance. Multigravida level of up to five using contraceptives shift the balance towards TH1 polarity. In other word, shift from cytokine balance towards in-balance state. Pill users showed balance, TH1 and/or TH2 polarity once in contrast to that noted by others during early, mid late gestation periods of pregnancy TH2 dominance. Hence contraceptives might acts as the way of antigen dependent immune modulant, but they are antigen independent modulants.

Keywords: Contrceptive, cytokine balance, TH1/TH2 paradigm, herd cytokine response.


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