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Abstract

SEMISOLIDS SYSTEMS ON A LIQUID-CRYSTALINE STRUCTURE BASE FOR THE PROLONGED RELEASE OF LIPOSOLUBLE ACTIVE INGREDIENTS.

Gastón Lillini, Claudia Salerno, Ricardo Pasquali†, Cristian Pedemonte, Carlos Bregni and Susana Lavaselli*

ABSTRACT

In the present work we set as objective to investigate the diffusion in
vitro over 48 h using Franz cells of a liposoluble active principle,
Econazole (ECZ), incorporated in emulsion prepared by conventional
techniques and in emulsions with liquid crystalline structure. The
concentration release of ECZ was determined by high performance
liquid chromatography (HPLC), using a mobile phase of methanol
water (50:50) on a gradient elution and a column of phase reverse C18
was used for the chromatographic separation. The conventional
emulsions exhibits a kinetic liberation that adjusts to the Higuchi
model during the 48 h of study, while the emulsions with liquid
crystalline characteristics adjusts to a kinetic liberation of order zero in
the firsts 8 h of study, such release is associated with the ECZ
dissolved outside of the liquid crystalline structure, and then with the
disintegration of the multilayer from the liquid crystalline, the ECZ incorporated in their
structure is released, allowing a controlled release.

Keywords: Liquid crystals, econazole, prolonged release, emulsions.


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