WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

NOVEL METHOD FOR CHROMATOGRAPHIC DETERMINATION OF SETRALINE AND DOXOFYLLINE IN FORMULATION BY USING RP-HPLC

Usha Kondla* and E. Esther Rani

ABSTRACT

A simple, rapid, selective, sensitive, linear, precise and accurate NOVALMETHOD FOR CHOMATOGRAPHIC DETERMINATION OF SETRALLINE AND DOXOFYLLINE. Tablet dosage form separation of drug was achieved on a reversed phase symmetry C18 column (150mm x 4.6mm) phosphate buffer was pH 3.5 & the mobile phase was optimized with consist of Acetonitrile, phosphate buffer mixed in the ratio of 30:70% v/v. The solution w3as chromatographed at constant flow rate of 1.0 ml / min. The UV detection wavelength was 234nm & 10 μm of sample was injected. Te linearity ranges of SERTRALINE & DOXOFYLINE were found to be 0.58μm from 1.77μg/ml of SERTRALINE & DOXOFYLINE 0.27 & 0.82μg/ml. Linear regression coefficient was more than 99-100% the value RSD is ranged from 0.37-0.53% indicating accuracy & precision of the method. LOD & LOQ were found to be within limit. The was validated as per ICH guidelines for its sensitivity, linearity, accuracy & precision. The method was successfully employed for routine quality control analysis SERTRALINE & DOXOFYLINE in its pharmaceutical formulations.

Keywords: Novalmethod for Chomatographic Determination of Setralline and Doxofylline.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More