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Abstract

ANTI-DIABETIC ACTIVITY OF CURCUMA NEILGHERRENSIS WT. RHIZOME EXTRACTS ON ALLOXAN INDUCED DIABETIC ALBINO RATS

Dandu Chaithra and Nimmanapalli Yasodamma*

ABSTRACT

Prolonged usage of present day drugs Sulphonylureas and biguanides against diabetes are causing the side effects like micro and macro vascular complications, renal failure, nerve diseases, blindness, obesity and arthritic problems. Hence World Health Organization also recommended for the search of herbal drugs which may reduce the risk of cardiac problems by reducing the lipid peroxidation and further regulates the plasma lipid and lipoprotein contents in the liver. Wild turmeric Curcuma neilgherrensis possesses many herbal uses as antiulcer, antidiabetic, anti-inflammatory, anti-arthritis, antimicrobial. Alloxan induced diabetic Albino rats were treated with aqueous and methanol extracts of rhizome and observed effective antidiabetic activity at 250 mg/kg b.wt after 21 days of daily treatment. Blood glucose levels are equal to that of normal and Glibenclamide standard drug treated rats and also no negative effects on body weights, haematological and biochemical parameters when compared to the diabetic rats. There is no any toxic effect upto 5000mg tested as per OECD 425 guidelines acute toxicity studies. Antidiabetic activity of C.neilgherrensis rhizome extracts also proved equal to that of C.longa, C.xanthorrhiza, C.raktakanta, Alpinia galanga. Hence it is proved as effective drug against diabetes as used by the tribals.

Keywords: Blood glucose, Acute toxicity, Glibenclamide, Biochemical, Histopathological.


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