WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

EVALUATION OF MIMOSA PIGRA ROOTS ON HAEMATOLOGICAL AND BIOCHEMICAL PARAMETERS OF ALBINO RATS

Shorinwa Olusayo A.*, Etozuo Nnamdi, Afieroho Ozadheoghene E.

ABSTRACT

To investigate the effect of sub-acute doses of the ethanol extract of mimosa pigra on haematological and biochemical indices in albino rats. Animals of both sexes were divided into four groups of six each. The extract treated groups were administered with oral doses of 250mg/kg, 500mg/kg and 1000mg/kg of the extract while the control received distilled water for 28 days consecutively. Blood samples were collected from the rats on the 29th day for evaluation of haematological (pcv, rbc and hb) and biochemical (ast, alt, alp, total protein, cholesterol, urea, creatinine and total bilirubin) parameters. The results of the study showed that there was a statistically significant (p<0.05) increase in packed cell volume, haemoglobin and red blood cell count at doses of 500mg/kg and 1000mg/kg. The extract produced no significant changes in the levels of total bilirubin, total cholesterol, total protein, aspartate aminotransferase, and alkaline phosphatase in all of the treated groups. But, a marginal statistically significant increase and a significant increase (p<0.05) in the level of alanine transaminase at doses of 500mg/kg and 1000mg/kg of the extract respectively were observed. Serum levels of urea, creatinine were not affected. The findings of this study has shown that the roots of mimosa pigra may be safe at doses below 500mg/kg but may pose toxicological risks at doses greater than 500mg/kg with the liver being the most affected on prolonged usage.

Keywords: Mimosa pigra, Sub-acute, Toxicity, Haematological, Biochemical.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More