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Abstract

DESIGN AND CHARACTERIZATION OF TRAMADOL HYDROCHLORIDE SOFT LOLLIPOPS

Nethravani G.*, Jagadeesh P. and Dasthagiri S.

ABSTRACT

The oral route is the most preferred route of administration of drugs
because of low cost of therapy, ease of administration, patient
compliance and flexibility in formulation. The illness are associated
with fever, head ache and body aches so to cure the above/relief from
the above, there was need to administer the drugs to the individuals but
in case of pediatric patients it was difficult to administer the dosage
forms like tablets, capsules, etc. In the present investigation an attempt
has been made to prepare and evaluate the sugar based medicated
tramadol hydrochloride soft lollipops for pediatrics to overcome the
administration. They were prepared by heating and congealing method
on laboraty scale with malt syrup as base. All the formulations were
subjected to various physico-chemical parameters such as hardness,
friability, content uniformity, weight variation, thickness, drug content and in vitro
dissolution studies. Drug-excipients compability stuidies were conducted by FT-IR
spectroscopy and results revealed that no interactions were found between drug and
excipients. The results of in vitro drug release studies showed that formulations F30, F33 and
F36releases the drug 94.4, 97.7 and 93.8 percentage at the end of 30 mins. The soft lollipops
can provide an attractive alternative formulation in the treatment of pain in pediatric patients.

Keywords: Tramadol Hydrochloride lollipops, HPMC: Hydroxy Propyl Methyl Cellulose, Na CMC: Sodium Carboxyl Methyl Cellulose, MC(Methyl Cellulose).


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