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Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NEWER TETRA ARYL IMIDAZOLES

Rohit Kumar*, Dr. Vikas Saxena and Dr. M. Hoque

ABSTRACT

In the present study we have made an attempt to synthesize novel imidazoles and evaluate them as potential therapeutic agents for antimicrobial and anthelmintic activity. First, Pyridine-4-amine was condensed with heteryl aldehydes to afford corresponding Schiff’s base. The Schiff’s base further on treatment with NH4OAC and isatin yielded corresponding aryl imidazoles. The synthesized compounds were analyzed by physical and analytical data. The synthesized compounds were evaluated for their anthelmintic and antimicrobial activity. All the synthesized substituted imidazoles have shown moderate to good anthelmintic activity. The synthesized imidazoles possessed significant antimicrobial activity against gram +ve bacteria S. aureus & B. subtilis and gram –ve bacteria E. coli & K. pneumoniae and antifungal activity against A. niger & C. albicans.

Keywords: Aryl imidazoles, Anthelmintic activity, Antimicrobial activity.


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