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Abstract

GREEN SYNTHESIS OF GOLD NANOPARTICLES (Au-NPs) USING Barleria cristata AND STUDY THEIR PHARMACOLOGICAL APPLICATIONS

S. Baskar*, G. Selvan, R. Anbarasu and V. Raja

ABSTRACT

Nano revolution is imperative to integrate nanoscience and medicine. Metal nanoparticles have several applications such as optics, biomedical sciences, drug delivery, catalysis and electronics. The present investigation deals with the green synthesis of gold nanoparticles (AuNP) using leaves extract of Barleria cristata for some pharmacological experiments. Several human pathogens were used to screen the antimicrobial properties and biological mechanism of gold nanoparticles (AuNPs) was studied with Hela cell line for their anticancer potentiality. Aqueous extract (pH 7.4 - inherent pH of the extract) was reacted with 1mM Chloroauric acid (HAuCl4.3H2O) and kept at room temperature. The immediate change in colour from pale yellow to pink indicated the reduction of Au 3+ ions to Au 0. The synthesized AuNP’s were monitored using UV-Visible spectrophotometer. X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning electron microscopy (SEM), and Dynamic Light Scattering (DLS). The invitro antimicrobial properties were confirmed by disc diffusion method on some human pathogens and their anticancer activity confirmed by MTT assay on the cell lines of Hela carcinoma cells showed IC50 values of extract at 50 μg/mL.

Keywords: Barleria cristata, Anticancer activity, Antimicrobial activity, Gold nanoparticles


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