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Sujita Manandhar*, Nijan Upadhyay, Sabyata Gautam and Sophie Ghimire


Polycystic ovarian syndrome (PCOS) is the most common endocrinopathy of women of reproductive age where up to 70% with PCOS remain undiagnosed. This study was carried out with a view to find out the psychosocial, metabolic and reproductive manifestations of PCOS and the management of the disease. It also aimed to find out the effect of PCOS on menstruation along with the incidence of pregnancy loss. This was a prospective and clinical study. The study was conducted at Infertility and Hormone Research Centre, Bijulibazaar, Kathmandu from July 2014 to November 2014. This study included women diagnosed with PCOS. Out of many patients, 130 patients falling into the inclusion criteria were selected for the study. In this study, age range of female suffering from PCOS was found to be from 21 to 41 years. The mean BMI was found to be 24.2882 ± 3.2689 kg/m2. 92.3% of women had high waist to hip ratio. The chief presenting complaint was found to be infertility. Primary infertility was the most dominating than secondary infertility. Among 122 women receiving fertility treatment, only 9.016% were pregnant.22.04% of women had a history of pregnancy loss, most of which were during first trimester. 8.5% of women had a family history of PCOS. In this study, 86.92% of the women had bilateral cyst. The women with PCOS had high FSH and LH value before treatment. Weakness was the most noticed side effect of the drugs. This study showed that 48% of the women had indications of depression. Body image disorder, eating disorder and sexual dysfunction was also noticed in majority of the women. Folic acid (89.65%), Metformin (82.75%), Clomiphene citrate (79.31%), Progestins (77.58%) were the most prescribed drugs. In this study, 41.66% of women had regular menstruation after taking medications. 8.62% achieved pregnancy and 3.176% had their miscarriages.

Keywords: Polycystic Ovarian Syndrome, psychosocial, reproductive, management, pregnancy, treatment.

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