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Abstract

ADVERSE DRUG REACTIONS DUE TO ANTI-TUBERCULAR DRUGS IN PATIENTS OF MULTIDRUG RESISTANT TUBERCULOSIS IN RAJINDRA HOSPITAL PATIALA

Dr. Vardhan A.*, Dr. Gupta A., Dr. Sehgal V.K., Dr. Kansal AP. and Dr. K. Sudesh

ABSTRACT

Patients with MDR-TB may be more likely to have had problems with non adherence in the past. In addition, adherence with MDR-TB therapy is made more difficult by its prolonged treatment regimens, with larger numbers of drugs that have more serious adverse effects. These adverse effects lead to non- adherence to the regimen, improper and inadequate drug intake by the patient and may lead to the further emergence of resistance. Therefore this study was done to know the Spectrum of adverse drug reactions caused by ATT. METHOD: 100 patients who were diagnosed as MDR-TB by Department of Chest and Tuberculosis Diseases, Government Medical College, Patiala were enrolled in the study over a period of December 2014 to march 2016. Detection and monitoring of ADR was done by interviewing patient and reviewing laboratory tests on monthly basis till their ATT continued. Patients were instructed to report any sign and symptoms they come across during the treatment period. RESULTS: Most of the patients were in age group 21-40 years. Male: Female patients were 75:25 patients with a ratio of 3:1. Most patients were in the weight range of 31-45 kgs. 30% patients had gastrointestinal symptoms as the common ADR, 18% with Sleep Disturbances, 15% with hearing loss,10% with joint pains, 7% with Allergic reactions. Out of 100, 11% patients were admitted only due to ADR’s caused by Drugs. CONCLUSION: All patients undergoing treatment for the disease should be closely assessed during initial periods after starting MDR regimen or at least monthly to identify and address potential adverse reactions. The reactions may range from inconsequential to severe and may be caused by medications other than those prescribed for TB drugs.

Keywords: ATT, ADR, DOTS PLUS.


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