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Abstract

STANDARDIZATION AND QUALITY CONTROL PARAMETERS OF SIDDHA POLY-MINERAL FORMULATION ‘DHASALAVANA DHRAVAGAM’

Ramani Mani*, Velpandian Venkatachalapathy and Nalina Saraswathi Kolappan

ABSTRACT

According to the traditional Siddha literature Kannusamiyam Ennum Vaidhiya Saegaram, the Siddha poly-mineral formulation of the tested drug Dhasalavana Dhravagam has unique properties being a specialized liquid form of medicine indicated for Poly Cystic Ovarian Syndrome. The aim of this present study was to standardize the purity, quality and safety of the tested drug Dhasalavana Dhravagam. The physico-chemical characterization of the tested drug was revealed by qualitative biochemical analysis and modern instrumental techniques such as Fourier Transformation Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM). Physico-chemical parameters revealed that the tested drug is a clear colourless liquid with no characteristic odour and specific gravity at 25˚C is 1.214, acidic (pH 5.7) in nature. The qualitative biochemical analysis revealed that the presence of Sulphate, Chloride, Phosphate, Calcium, Sodium, Potassium, Magnesium, Ammonium, Iron, Zinc and Copper. The FT-IR study revealed the presence of functional groups like phenols and alcohols, amine, primary amines, nitro groups, nitro methane, alkyl halides in Dhasalavana Dhravagam. The SEM analysis showed that the size of the particles to be 119nm, 122nm, 150nm, 159nm, 166nm in the tested drug. So it was concluded that the Dhasalavana Dhravagam contains essential elements which are responsible for curing PCOS. Also the drug possesses no toxic metals which ensures its safety in therapeutic usage.

Keywords: Dhasalavana Dhravagam, Siddha, PCOS, Physico-chemical, instrumental analysis, poly-mineral formulation.


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