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Abstract

ASSESSING THE ANTICANCER, ANTIINFLAMMATORY, ANTIMICROBIAL AND ANTIOXIDANT POTENTIAL OF BIOACTIVE COMPOUNDS PRESENT IN MARINE ALGAE ULVA LACTUCA

Sujina M. G., Soumya J. D. and W.A. Manjusha*

ABSTRACT

Background: The discovery and development of antibiotics are among the most powerful and successful achievements of modern science and technology for the control of infectious diseases. The present study was performed to investigate the bio activities of the marine algae, Ulva lactuca collected from south west coast of India. Objective: The collected alga was subjected to screen phytochemicals, antimicrobial activity, and antioxidant, anti inflammatory and anticancer activities. The bioactive compounds were identified by GC–MS analysis. Extracts of the algae was prepared using methanol, ethyl acetate, chloroform, petroleum ether, acetone and hexane. Materials and methods: The antibacterial activity was carried out by disc diffusion method, antioxidant activity by diphenyl picrylhydrazyl and reducing power method, anti inflammatory activity was determined by COX inhibitory assay, anticancer activity by dimethylthiazol diphenyl tetrazolium bromide (MTT) and GCMS analysis performed using an Agilent GC-MS 5973 assembly equipped with a HP-5crosslinked fused silica capillary column. Result: phytochemical analysis shows the presence of carbohydrate, saponin, flavanoids steroids, tannins, alkaloids, terpenoids and phenol. Antimicrobial activity of algal extract showed highest activity against Bacillus subtilis (12mm) and Candida tropicalis (20mm). Methanol extract of Ulva lactuca showed highest antioxidant activity compared to other extracts and also methanol extract possess cytotoxic activity against SKMEL skin cancer cell line. Through GC-MS analysis twelve organic compounds were separated among that Cyclo (L-Pro-L-Val) was more abundant in chromatogram. In the present study it was concluded that the Ulva lactuca is a source of pharmaceutical important compounds used for the treatment of human pathogenic diseases, anti-inflammatory and cancer.

Keywords: Ulva lactuca, phytochemical analysis, antimicrobial activity, antioxidant activity, anti-inflammatory activity, anticancer activity, GC-MS analysis.


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