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Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR ESTIMATION OF MILRINONE IN FORMULATION

Ranjith Kumar D.*, Mohan S., Vanathi P., Prakash G., Sasikala M., Karpakavalli M.

ABSTRACT

Simple, specific, sensitive, reproducible, precised and cost effective UV spectroscopic method for Milrinone in single dosage form has been developed. Milrinone is used in the treatment of congestive heart failure. In the estimation of Milrinone by UV spectroscopy, the λmax was found to be 271nm for Milrinone in solvent methanol. The calibration curve was obtained for Milrinone in the range 1.0- 10.0g/ml. The slope, intercept and correlation coefficient values were found to be 0.0594, 0.0672 and 0.9989 respectively. The 50% and 100% recovery studies were carried out for formulation 1 and formulation 2 by adding known amount of standard drug. The related standard deviation (%RSD) was ˂2%. The stability studies were carried out and the drug was found to be stable more than 12 hours in solution form. Thus, the developed validated UV spectroscopic method can be used for the routine analysis of Milrinone from its single dosage form in research institutions, laboratories and educational institutions.

Keywords: Milrinone, UV spectroscopy, methanol, validation, % RSD, injection.


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