WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60


Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here


Track Your Article



Cheruku Alekhya and Nimmanapalli Yasodamma*


Arthritis has become very common among the adult population above 50 years of age nearly 0.5-1% of the world population. It is two to three times common in women than men. Arthritic disorders comprise a group of more than hundred rheumatic diseases, osteoarthritis and rheumatoid arthritis (RA) is the most prevalent forms share a similar outcome of joint destruction. American College of Rheumatology (ACR) and European League against Rheumatism (EULAR) developed new criteria for RA diagnosis including joint evaluation, duration of symptoms, serologic tests and acute phase response Erythrocyte sedimentation (ESR) and CRP-C reaction protein. Symptom Modifying Anti-rheumatic Drugs (SMARDs), hydroxyl chloroquine, cyclosporine, azathioprine, D-penicillamine auranofin and intra muscular gold are widely used to control rheumatism. Analgesics are used to reduce pain; anti-inflammatory drugs (Non-steroidal) cause several adverse effects being gastro intestinal toxicity and renal damage. Highly selective drugs on the inhibition of cyclooxygenase enzyme COX-1 and COX-2 known as Coxibs (Celecoxib and Rofecoxib) claimed low gastrointestinal (GI) side effects. But found increased risk of heart attack and stroke hence rofecoxib was withdrawn worldwide. Treatment with analgesics include drug therapy to alter the nociceptive and physiologic response in addition to cognitive behavioural strategies as distraction, relaxation to alter the physiological response. Most of the analgesic drugs inhibit prostaglandin synthesis in the periphery. Hence male cone extracts Cycas beddomei of an endemic medicinal plant on CFA induced arthritis male rats has been carried out and observed its efficacy at 250 mg/kg b.wt equally to that of the standard drug treated rats in reducing arthritis inflammation, maintaining haematological and biochemical parameters including radiological analysis in reducing bone destruction at joint spaces.

Keywords: Rheumatoid arthritis, osteoarthritis, non-steroidal anti-inflammatory drugs, cyclooxygenase, haematological, biochemical.

[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More