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Abstract

NOVEL MONOCYCLIC β-LACTUM MOLECULES: DESIGNED AND CHARACTERIZED AS POSSIBLE ANTIBACTERIAL AGENTS

Vikas A. Desai*, Tejaskumar J. Shah and Bhadreshkumar R. Sudani

ABSTRACT

A reaction of Schiff bases (1a-j) with monochloro acetyl chloride afforded a series of 1-[4’-(2”,4”-dichloro-5”-fluoro phenyl)-6’-(2”- thienyl)pyrimidin-2’-yl-ureido]-4-substituted phenyl-3-chloro-2- azetidinone derivatives (2a-j) in moderate yields. All the monocyclic β-lactam products have been characterized on the basis of physical properties of the molecule and satisfactory spectral (IR, 1H NMR) data. The mechanism of formation of the product is shown. The antibacterial activity of the compounds against some Gram (+) and Gram (-) bacterial strains is reported.

Keywords: Cyclocondensation, Schiff base, Monocyclic ?-lactam, Amide linkage, Antibacterial activity.


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