WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

PROGESTERONE ADMINISTRATION DURING PREGNANCY IS EMBRYO-TOXIC.

Insaf Jasim Mahmoud*, Nawal Khairy Al-Ani and Hanaa Ahmed Faris

ABSTRACT

Background & objectives: Progesterone is a therapeutic agent in human pregnancy but its effects on the developing embryo and fetus have long been a concern. We aimed to find any changes in the morphology of the reproductive system and in blood levels of estrogen and progesterone of females mice exposed to progesterone during intrauterine life. Methods: Ninety adult pregnant mice were divided into three groups and injected daily with two different doses of progesterone for fourteen days: G1, control group: sesame seed oil; G2: progesterone at a dose of 0.4 mg / kg body weight (BW) / day and G3: progesterone at a dose of 0.8 mg /kg BW / day. New borne females were sacrificed at zero day, one month and two months of age. Morphology and morphometry of reproductive system were studied and hormonal assay was performed. Results: At one and two months after birth, there was a highly significant increase (P < 0.01) in the anogenital distance and a highly significant decrease in the number of corpora lutea. At one month after birth there was a highly significant decrease in the number of ovarian follicles. At the age of two months, there was a highly significant decrease in the height of epithelial cell layer and a highly significant decrease in the diameter of ovarian follicles. There was a highly significant decrease in estrogen and progesterone levels. All changes were in both G2 and G3. Interpretation & conclusions: The administration of progesterone during pregnancy has adverse effects on certain aspects of the reproductive system of female embryos indicating that progesterone is embryo toxic.

Keywords: Anogenital distance, morphometry of ovarian follicles, progesterone teratogenicity.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More