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Abstract

TUMOR NECROSIS FACTOR ALPHA AND INTERLEUKIN 6 IN ESSENTIAL HYPERTENSION

Rihab Akasha Mohamed*, Amar Mohamed Ismail, Omer Fadul Edris,
Siddig Bushra Mohamed.

ABSTRACT

Background: Epidemiological and experimental studies have revealed an association between biochemical markers of systemic inflammation and cardiovascular disease such as atherosclerosis, heart failure, and hypertension. Increased production of tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) which might play an important role in the initiation and progression of hypertension by a variety of mechanisms such as giving rise to contraction of vessels, leading to thickening of vascular wall, and proliferation of endothelial cells and smooth muscle cells. Aim: The aim of this study to evaluate the concentration of TNF-α and IL-6 in essential hypertension and correlate it with duration of hypertension and others study variable. Material and methods: 250 patients with essential hypertension and 250 healthy individual as control. Serum and urine were collected after fasting 8 hours overnight; serum used for measurement of TNF-α, IL-6 (by using ELISA technique). And urine used for estimation of microalbumin/creatinine ratio (MCR) by turbidimetryspectorphotometry method. SPSS 20 software and Microsoft Office Excel were used for statistical analysis. Result: The mean value of TNF, IL-6 and MCR were significantly increased in patients than controls, with (P-value 0.000). Highly significant correlation between IL-6 and age, blood glucose, urea, creatinine, duration of hypertension and SBP. No correlation between IL-6 and gender, BMI and DBP. Also there were highly significant correlation between TNF and age, blood glucose, urea, creatinine, duration of hypertension and SBP. No correlation between IL-6 and gender, BMI and DBP. There were significant correlation between MCR and gender, age, blood glucose, urea, creatinine, and duration of hypertension. No correlation between MCR and BMI, SBP and DBP. Conclusion: TNF-alpha and IL-6 also are significantly increased in hypertension and may use in early detection of renal disease in hypertensive patients.

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