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Abstract

CHEMICAL AND PHARMACOLOGICAL STUDY OF THE PANCREOPROTECTIVE REMEDY

Nikolaev S. M., Nikolaeva I. G.*, Razuvaeva Ya. G., Radnaeva L. D.,
Geriletu B. and Dylenova E.P.

ABSTRACT

The researches has shown that the complex plant remedy conventionally named “Pancreophyt” contains tannins from 4,76 to 5,20% (including 0,12% of ellagic acid), flavonoids (including 0,10% of quercetin, 0,67% of rutin, 0,18% of luteolin, 0,009% of luteolin-7- glycoside), polysaccharids from 4,0 to 4,2%, 0,04% of oleanolic acid, ascorbic acid from 3,6 to 3,9%. The extract “Pancreophyt” has the marked pancreoprotective effect in the triton-induced pancreatitis, decreasing the activity of α-amylase (by 24% on the 21st day of the experiment; p<0,05) and reducing the intensity of inflammatory reaction: the leucocyte content is decreased by 25% at the average (p<0,05), ESR index is 1,4 and 2,1 times decreased on the 14th and 21st days of the experiment respectively (p<0,001).

Keywords: Pancreoprotective complex plant remedy, HPLC, Bidens tripartita L., Gnaphalium uliginosum L., ?alendula officinalis L., Inula helenium L., Pentaphylloides fruticosa L., Hypericum perforatum L., Vaccinium myrtillus L.


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