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Abstract

THE DEVELOPMENT OF DIFFERENT FORMULATIONS CONTAINING 2% CHLORHEXIDINE DIGLUCONATE AND PRELIMINARY EVALUATION OF THE STABILITY OF THE FORMULATIONS.

Ítalo Mendes Cangussú, Thalles Yuri Loiola Vasconcelos*, Débora Patrícia Feitosa Medeiros, Raimundo Jeová Martins Mesquita, Francisca Valéria Bezerra Sampaio Marques, Raphael Lucas de Vasconcelos Saraiva, Aristides Ávilo do Nascimento

ABSTRACT

Hand washing using soap for degerming is essential to reduce the risk of infection, and it is preferable to use antiseptic liquid soaps. A chlorhexidine digluconate solution at low concentrations acts as a bacteriostatic agent, and as a bactericidal agent at higher concentrations. This study aimed to analyze different liquid soap formulations containing 2% chlorhexidine gluconate and analyze which of the formulations has adequate stability. Twelve formulations were produced containing chlorhexidine with different concentrations of hydroxyethylcellulose and citric acid. After preparation, the samples were submitted to centrifugation and a thermal stress test and analyzed for the presence of signs of instability. Of the twelve samples analyzed, eleven showed signs of instability in both tests. Only the formulation containing 1% hydroxyethylcellulose and 0.5% citric acid showed adequate stability. The preliminary stability study led to the selection of the best formulation for the development of liquid soap containing 2% chlorhexidine digluconate, and this was the formulation with 1% hydroxyethylcellulose and 0.5% citric acid.

Keywords: Chlorhexidine, Cosmetic stability, Preliminar stability study, Soaps.


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