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Abstract

EXPLORATION OF ANTI-OVARIAN ANTIBODIES IN FEMALES UNDERGOING INTRAUTERINE INSEMINATION AND IN VITRO FERTILIZATION; A PRELIMINARY STUDY

Isra Elabbas Abdelrahman* and Abdalla Hassan Sharief

ABSTRACT

The current study has been carried to investigate the existence of antiovarian antibodies (AOA) in women undergoing intrauterine insemination (IUI) or in vitro fertilization (IVF). Serum samples from 21 women undergoing IUI, 24 women undergoing IVF and 25 fertile healthy controls were examined for the presence of anti-ovarian antibodies using ELISA method. AOA has been positive in 35.5% of infertile women, while none of the fertile controls were positive for AOA. The levels of these antibodies increased proportionally with the patient's age and the number of treatment attempts. Though the presence of AOA did not affect oocyte recovery rate, it resulted in decreased fertilization rate, cleavage rate, and pregnancy rate in infertile women. Moreover, these antibodies may also stuck pregnancy after IVF or IUI procedure as they attack the fertilized ova and thus ended up with a lower pregnancy rates. The study concluded that anti-ovarian antibodies might be a cause of premature ovarian failure in females who did IUI or IVF procedures. Also advanced age of women is not associated with lower pregnancy rates after IVF. that anti-ovarian antibodies may be a cause of infertility and existence of these antibodies could have adverse effects on the outcome of assisted reproductive techniques.

Keywords: In vitro fertilization, AOA, intrauterine insemination, Sudan.


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