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Abstract

SEDATIVE AND ANXIOLYTIC ACTIVITIES OF METHANOL EXTRACT OF LYGODIUM PALMATUM (BERNH.) SW. LEAVES.

Mahmudul Hasan, Mohammad Shah Hafez Kabir*, Md. Abu Aiube Ansary, Md. Rakibul Hasan, Md. Nazmul Huda, Shefatun Nur, Sagar Shil, Akter Hossen, Joy Chakraborty, Abul Hasanat and Md. Rabiul Islam

ABSTRACT

Background: Lygodium palmatum (Bernh.) Sw. leaves are deliberated as worthy traditional medicine. To give a scientific basis for traditional usage of this medicinal plant, the methanol leaf extract (MELP) was used for its sedative and anxiolytic activities. Methods: In this study, the sedative activity was also evaluated using open field test, hole cross test. Besides, elevated plus maze test, hole-board test for exploratory behavior in mice were used to evaluate its anxiolytic activities. The in vivo action was done using mice of both sexes. Result: The extract showed a dose dependent sedative effect. The number of squares traveled by the mice was decreased significantly (P<0.01) from its initial value at 0 to 90 min at the dose of 400 mg/kg body weight of the extract. In the EPM, the behavior of mice model, as observed, confirmed the anxiolytic activity of diazepam as reported previously. The methanol extract of L. palmatum leaves (MELP) at the dose of 400 mg/kg, significantly increased the time spent in the open arms. Hole Board test proved that the extract have significant anxiolytic activity. Because, head dipping of mice increased with the tested treatment. Conclusion: The obtained results support that L. palmatum has well sedative and anxiolytic effects and deserve further investigation to isolate the specific components that are responsible for the sedative and anxiolytic effects. Components from this plant may have a great potential value as medicinal agents, as leads or model compounds for synthetic or semi synthetic structure modifications and optimization.

Keywords: Lygodium palmatum, Sedative, open field, Anxiolytic, EPM.


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