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Abstract

DRUG TARGETS IN LEPROSY

Thirupathy Kumaresan Paraman, Thiruppathi Murugesen, Vijay Nagendiran Perumal*

ABSTRACT

Leprosy is contagious disease caused by mycobacterium leprae (Acid fast bacteria). It is the leading cost of mortality among all other infectious disease. The emergence of resistance form’s of leprosy strong epidomological existence AIDS, due to expand treatment with chemical and associated side effect of the exisisting drug fundamentals new and more effective drug to treat the leprosy and tuberculosis. In this record the structural genomic’s mycobacterium leprae provide very important information to identify the potential target for the development of newer anti-leporal agent’s. In addition the genome of mycobacterium leprae encoded a serious of target’s that are unique in mycobacterium leprae. But are absent in host cell’s. This target can particularly in hibit the growth of mycobacterium leprae enhance to reduce side effect, inhibit resistance development and removal of latent disease. In this review a new target particularly those widely cited in literature with structure containing potential inhibitor (or) substrate (or) structure based design of drug’s which can be development of drug’s which can be development of antileprosy drug.

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