DRUG TARGETS IN LEPROSY
Thirupathy Kumaresan Paraman, Thiruppathi Murugesen, Vijay Nagendiran Perumal*
ABSTRACT
Leprosy is contagious disease caused by mycobacterium leprae (Acid
fast bacteria). It is the leading cost of mortality among all other
infectious disease. The emergence of resistance form’s of leprosy
strong epidomological existence AIDS, due to expand treatment with
chemical and associated side effect of the exisisting drug fundamentals
new and more effective drug to treat the leprosy and tuberculosis. In
this record the structural genomic’s mycobacterium leprae provide
very important information to identify the potential target for the
development of newer anti-leporal agent’s. In addition the genome of
mycobacterium leprae encoded a serious of target’s that are unique in
mycobacterium leprae. But are absent in host cell’s. This target can
particularly in hibit the growth of mycobacterium leprae enhance to
reduce side effect, inhibit resistance development and removal of latent
disease. In this review a new target particularly those widely cited in
literature with structure containing potential inhibitor (or) substrate (or) structure based
design of drug’s which can be development of drug’s which can be development of antileprosy
drug.
Keywords: .
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