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Abstract

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF CURCUMIN AND PIPERINE IN BULK MIXTURE.

Mamta Y. Chahar and Dr. Rajashree Mashru*

ABSTRACT

A new RP-HPLC method has been developed and validated for simultaneous estimation of Curcumin and Piperine, present method is found to be simple, rapid, precise, accurate, specific and stability indicating. Column used was Synchronis C-18 (250 mm x 4.6 mm 5 μm), mobile phase consist of water (0.1%acetic acid): Acetonitrile in 40:60v/v ratio to achieve good resolution and retention of analytes and its impurities. Detector linearity was established in concentration range curcumin 25-125 μg/ml, piperine 0.25-1.25μg/ml. The regression coefficient was 0.9979 for curcumin and 0.999 for piperine. The analyte was exposed to stress conditions such as acid, base, oxidation, neutral and sunlight as per ICH guidelines recommendations. Method was validated in terms of linearity, specificity, precision, accuracy, limit of detection and limit of quantification, results were found to be satisfactory and offers good column life.

Keywords: Curcumin, Piperine, Stability, RP-HPLC.


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