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Abstract

DEVELOPMENT AND VALIDATION OF HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS ESTIMATION OF TEMOZOLOMIDE AND CAPECITABINE IN SYNTHETIC MIXTURE

Pooja B. Patel* and Paresh U. Patel

ABSTRACT

The present manuscript describe simple, sensitive, rapid, accurate, precise and economical High Performance Thin Layer Chromatographic (HPTLC) method for the simultaneous determination of Temozolomide and Capecitabine in synthetic mixture. In HPTLC method two drugs were spotted and development of plate was carried out. Plate was scanned and peak areas were measured densitometrically at 316 nm for quantitation of TEM and CAP. The linearity was achieved in the concentration range of 100-350 ng/spot for both Temozolomide and Capecitabine. The concentrations of the drugs were determined by using regression line equations. From results of recovery studies it can be concluded that there are no interferences from the excipients. The method was found to be simple, sensitive, accurate and precise. So, it can be applicable for the simultaneous determination of Temozolomide and Capecitabine in synthetic mixture. The results of analysis have been validated statistically and by recovery studies.

Keywords: Temozolomide, Capecitabine, HPTLC method, Synthetic mixture, Validation.


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