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Abstract

CNS ACTIVITIES OF AQUEOUS EXTRACTS OF CITRUS LIMON AND CITRUS SINENSIS AND ITS COMBINATION STUDIED IN MICE

G. Abhinayani*, Kraleti Shravya, Rani Snigdha and K. Sirisha

ABSTRACT

The Citrus limon and Citrus Sinensis exhibits many important natural components, including citric acid, ascorbic acid, minerals and phenolic compounds, such flavonoids. Although their biological properties have always been associated with their content of vitamin C, it has recently been shown those flavonoids and other nutrients and non-nutrients (vitamins, minerals, dietary fiber, essential oils and carotenoids). Therefore, their health-promoting effects, such as obesity, diabetes, blood lipid lowering, cardiovascular diseases, brain disorders and certain types of cancer, have been associated with their contents, especially vitamin C and flavonoids, due to their natural antioxidant characteristics. Therefore, this work was designed based on phytochemical constitution such as flavonoids in Citrus limon Citrus Sinensis peel extracts because flavonoids are rich in the treatment for evaluation of CNS activities in mice. Fresh and crushed peel of Citrus limon and Citrus Sinensis peel were collected and then extracted with solvents such as water, and the doses of 20 mg/kg body weight is given for an mice. CNS activities were performed by using a Forced swim test, Tail Suspension test, Actophotometer test, Rota rod test and Muscle Grip strength in mice. Diazepam 5mg/kg was used as standard drug for these studies. In the present study, the aqueous peel extracts of Citrus limon, Citrus Sinensis and its combination was demonstrated significant CNS activities in the tested models.

Keywords: Citrus limon and Citrus Sinensis, Forced swim test, Tail Suspension test, Actophotometer test, Rota rod test, Muscle Grip strength and Diazepam.


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