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Abstract

ASSOCIATION OF VITAMIN D STATUS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASES AND ITS EXPLANATORY VARIABLESIN BURDWAN

Dr. Mrinal Pal, Dr. Subinay Datta, Dr. Ritabrata Mitra, Dr. Tarasankar Malik, Dr. Soumi Pal

ABSTRACT

Background: Chronic Obstructive Pulmonary Diseases patients may be at increased risk for vitamin D deficiency, but risk factors for deficiency among these patients have not been extensively studied.Aim:The present study was conductedto investigate the association between important explanatory variables of Chronic Obstructive Pulmonary Diseases with circulatory level of vitamin D. Methods: Serum vitamin D level was measured by chemiluminescencemethod in 552 patients and 521 controls. Different explanatory variables of Chronic Obstructive Pulmonary Diseaseswere examined for associations with vitamin Din linear regression models.Results: Serum vitamin D levels were significantly lower in patients than controls (p<0.0001). The patients had an increased risk for vitamin D deficiency even after adjustment for different explanatory variables. Variables associated with lower vitamin D levels in patients were obesity (95% CI 0.009 to 0.079; p = 0.014), current smoking (95% CI -0.174 to -0.131;p = < 0.01), Global Initiative for Obstructive Lung Disease stage III- IV (95% CI 0.388 to 0.438; p < 0.01), Comorbidity (95% CI 0.139 to 0.157; p = 0.027) and depression (95% CI -2.399 to -2.117; p < 0.01). Conclusion: Vitamin D deficiencies can exist in Chronic Obstructive Pulmonary Diseases even after adjustment different potential variables.

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