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Abstract

SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR AMLODIPINE BESYLATE AND SIMVASTATIN IN BULK AND TABLET DOSAGE FORM USING ABSORPTION RATIO METHOD

Sathis Kumar Dinakaran*, Koyya SivaKumar, Anusha Pothula, Avasarala Harani

ABSTRACT

A simple, economic and accurate absorption ratio method was developed for the simultaneous estimation of Amlodipine besylate and Simvastatin in bulk and tablet dosage form. 0.1M HCL in 1% Sodim Lauryl Sulphate was used as a diluent. The absorptions were observed at 249.78nm and 367.85nm which were selected based on overlap spectra of Amlodipine besylate and Simvastatin. The Linearity range was found to be 5-30ug/ml (r2 =0.999) at 249.78nm and (r2 = 0.996) at 367.85nm. The proposed method was validated. The reports was expressed that the proposed method was found to be simple, precise, accurate and rapid for the simultaneous estimation of Amlodipine besylate and Simvastatin in bulk and tablet dosage form using absorption ratio method.

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