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Azad Matari, Ali Nazeri Astaneh*, Pantea Faridnia and Neda Alibeigi


Background: The aim of this study was to determine the efficacy of emotional regulation on the severity of depression as the world’s most debilitating disease in these decades. Methods: This randomized clinical trial conducted 24 out-patient subjects with diagnose of major depressive disorder. They were randomly assigned to two groups receiving serteralin (50-150 mg) daily and emotional regulation therapy or serteralin alone for 12 weeks. In first and last sessions symptoms were assessed by Beck Depression Scale and Emotion Regulation Questionnaire in both groups. Results: the emotional regulation group showed significant difference in depression (p <0/02) and in terms of emotion regulation strategies (p <0/0001) compared to other group. Both groups showed significant differences between pretest and post-test (p <0/0001). Conclusion: Emotion regulation therapy plus medication in the treatment of major depressive disorder is more effective than medication alone. This is more effective in improving emotional and cognitive symptoms than physical symptoms. This method improves emotional regulation skills in patients who were undergoing psychotherapy.

Keywords: major depressive disorder, emotion regulation, cognitive symptoms.

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