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Abstract

THE BENZOYLSALICYLAMIDE AND THE 4- FLUOROBENZOYLSALICYLAMIDE, THE NOVEL SALICYLAMIDE DERIVATIVES AND THE ANALGESIC ACTIVITIES COMPARATIVE

Bambang Tri Purwanto*

ABSTRACT

The benzoylsalicylamide and the 4-fluorobenzoylsalicylamide as the novel salicylamide derivatives had been synthesized. The novel compound benzoylsalicylamide and the 4-fluorobenzoylsalicylamide were synthesized by The Schotten Baumann method, where the reaction were between salicylamide and benzoyl chloride also 4- fluorobenzoyl chloride. The analgesic activity test was done for the benzoylsalicylamide and the 4-fluorobenzoylsalicylamide compound by writhing test and compared with salicylamide as the standard compound. The benzoylsalicylamide compound yield was 58%, had a crystal shiny white needles and gave one spot in Thin Layer Chromatography with three different eluents. The compound melting point was different from the salicylamide and showed greater. The structure identification from the new compound was analysed by UV, IR, 1-H-NMR, the result showed that the novel compound was benzoylsalicylamide. The analgesic activity test from benzoylsalicylamide had a greater activity if compare with the standard compound salicylamide. The 4-fluorobenzoylsalicylamide compound yield was 64% had a white powder and gave one spot in Thin Layer Chromatography with three different eluents. The compound melting point was different from the salicylamide and showed greater. The structure identification from the new compound was analysed by UV, IR, 1-H-NMR, the result showed that the novel compound was 4-fluorobenzoylsalicylamide. The analgesic activity test from 4-fluorobenzoylsalicylamide had a greater activity if compare with the standard compound salicylamide also from the benzoylsalicylamide. The benzoylsalicylamide and 4- fluorobenzoylsalicylamide had been synthesized as the novel salicylamide derivatives and the 4-fluorobenzoylsalicylamide had a higher analgesic activity if compare with salicylamide as the standard compound also from the benzoylsalicylamide.

Keywords: Benzoylsalicylamide; 4-fluorobenzoylsalicylamide; Synthesis; analgesic activity test.


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