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Abstract

BIOCHEMICAL PARAMETERS AND SPERM CHARACTERISTICS IN MALE RATS GIVEN PLANTAIN STEM JUICE IN CYCLOSPHOSPHAMIDE-INDUCED REPRODUCTIVE TOXICITY

Arhoghro E. M.*, John T. R.1, Eboh A.S., Prohp T. P. and Angalabiri-Owei B.

ABSTRACT

Aim: This study was aimed at determining the efficacy of plantain stem (Musa paradisiaca) juice in reversing the cyclosphosphamide (CP) induced reproductive toxicity in rat model. Study design: The twenty male rats (Wistar strain) were divided into 4 groups with each group having 5 rats. The rats in group 1 and 2 (negative and positive control) were administered with distilled water and cyclophosphamide (6mg/kg body weight) respectively, while Group 3 was given cyclosphosphamide orally at the dose of 6 mg/kg body weight. However, group 3 was treated with plantain stem juice (2 mg/kg body weight) 1 hour after CP administration once daily for 21 days. Group 4 was treated with plantain stem juice alone also for 21 days. Methodology: Semen characteristics, serum testosterone, FSH, LH, testicular anti-oxidant enzymes, lipid peroxidation and histopathology of testes were the parameters assayed using Light microscopy and biochemical methods. Results: The degree of sperm cell mortility; sperm count was significantly decreased (p<0.05) with an increase (p<0.05) in the abnormal and dead sperm in animals administered with CP (Group 2) compared to animals in the control group. Also serum FSH and LH levels were significantly reduced (p<0.05) with increase serum testosterone level in the rats which received a co-treatment of plantain stem juice and CP (6mg/kg) when compared to the rats which took CP alone. A significant increase in MDA concentration and decreases (p<0.05) in superoxide dismutase and glutathione peroxidase activities was noted in group 2 compared to the control group. Notably, plantain stem juice co administration and plantain stem juice alone compared favorably with the negative control in all the parameters. Testes of Animals co-treated with plantain stem juice displayed nearly normal histoarchitecture and signs of recovery when compared with the control. Conclusion: These findings indicate that plantain stem juice is protective against CP- induced reproductive toxicity.

Keywords: Musa paradisiaca biochemical parameters, oxidative disturbances, sperm characteristics.


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