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Abstract

SILVER STAINED NUCLEOLAR ORGANIZING REGIONS (AGNOR) IN CHRONIC LYMPHOID LEUKEMIAS

Dr. Estabraq Abdul Hussein*

ABSTRACT

CHRONIC LYMPHOID LEUKEMIAS Definition Are a complex group of disorders characterized by clonal neoplastic proliferation of cytologically and immunophenotypically mature lymphocytes (B, T and NK) with predominant blood and bone marrow manifestations. Classification of chronic lymphoid leukemias 1- The French – American – British group proposal for the classification of chronic lymphoid leukemias (1989) 2- The REAL classification (1994) 3- The proposed WHO classification of lymphoid neoplasms (1997) CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) Diagnosis The International Workshop on CLL, IWCLL (1981, updated in 1989) proposed the following criteria for the diagnosis of CLL: 1- A sustained peripheral blood lymphocyte count greater than10 109/L with most of the cells being mature-appearing lymphocytes. 2- Bone marrow aspirate showing greater than 30% lymphocytes. 3- Peripheral blood lymphocytes identified as monoclonal B cells. The diagnosis of CLL is confirmed if criteria 1 plus 2 or 3 are present. If the peripheral blood lymphocyte count is less than10109/L then both criteria 2 and 3 must be present.

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