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Abstract

NOSE TO BRAIN DELIVERY AND DIFFERENT STRATEGIES FOR CNS DRUG DELIVERY

Tripathi Sapna*, Mukhopadhyay Sayantan and Kothiyal Preeti

ABSTRACT

Nose is an invasive route for delivery of drug to the CNS. For the delivery of drug to the CNS the major challenge is to crossing of BBB. So researches develops many strategies by which drug can be directly goes to CNS for treating many CNS diseases. Nasal delivery is one of them. In the nasal delivery lipophilic drugs are well absorbed and directly goes through the olfactory region to cerebrospinal fluid in the brain. When the other route are not allowed for low molecular weight drugs then nasal route is preferred. Nasal route is used because it protect from first pass metabolism, the surface area of nose is large, good penetration, rapid absorption, avoidance of harsh environment etc. Nasal route offers lower risk of overdose of CNS acting drugs because in this delivery drug dose is less than the other delivery. Many nasally applied dosage forms are available in market. Two third are locally acting decongestants and one third comprises a number of antimigraine drugs, peptide hormone analogs and nicotine nasal spray, all with the systemic effects. Now intranasal administration of drug delivery to brain especially for the treatment of CNS drug such as depression, epilepsy, angina pectoris, migraine etc.

Keywords: BBB, Intranasal, different strategies, Marketed formulation of Nose delivery.


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