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Abstract

SYNTHESIS, CHARACTERISATION AND INTERACTION STUDY OF COBALT (III) EDTA AZIDO COMPLEX WITH BSA AND DNA

V.Violet Dhayabaran, M.Malathi, T.Daniel Prakash, V. Kalaiselvi

ABSTRACT

Complex has been synthesized by simple chemical method and characterized using Infrared spectral analysis, UV-Visible spectral analysis and Cyclic voltammetry. The interaction between [Co(HEDTA)N3] with BSA and CT-DNA has been studied by UV– visible and Fluorescence spectral analysis. The results presented clearly indicates that the [Co(HEDTA)N3]- complex enhances the absorption of BSA and DNA through complex formation. Binding studies of [Co(HEDTA)N3]- complex has been investigated with the protein BSA and CT-DNA by UV-Visible spectrometry measurements and the apparent binding constants were determined. Experimental data reveals that the emission profiles of EB in the absence and presence of CT-DNA. EB does not emit fluorescence, but its emission intensity in the presence of DNA is greatly enhanced, due to its not strong intercalation between the adjacent DNA base pairs. Binding studies of [Co(HEDTA)N3]- complex has been investigated with the protein BSA and CT-DNA by fluorescence spectral measurement. The binding constant were determined.

Keywords: Cobalt, Azido, DNA, BSA.


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