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Aggarwal Deepanshu, Amanpreet Kaur, Goyal Amit*, Singh Gurpreet, Kamboj Anjoo, Jain Upendra K.


The present paper reviews on pathophysiology, pharmacotherapy and latest treatment used for the obesity. The objective of the review is to update the knowledge with a complementary angle and perspective. Obesity is essentially an excessive accumulation of triacylglycerol in fatty tissue that is the net result of excessive energy intake compared to energy usage. It is a multifactorial, chronic disorder with complex interaction between genetic and environmental factors. It is the major health burden in the western world, in terms of increased risk of diabetes (type 2), cardiovascular morbidity, cancer and also in economic costs to healthcare providers. It also increases the risk of several malignancies in breast, colon, pancreas, and endometrium. The various etiological factors responsible for the development of disease include sedentary lifestyle/physical activity, genetic determinants, excess of calorie intake, environment factors, various health disorders etc. Numerous different types of drug which had been used in the past for the treatment of obesity have currently been withdrawn due to undesirable long-term side effects. Current insights provided by the new biology are leading to the development of novel anti-obesity drugs with central/anorexigenic effects.

Keywords: BMI, haematopoiesis, NAFLD, ARC.

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