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Abstract

A REVIEW: GRANULATION TECHNOLOGY FOR PHARMACEUTICAL PRODUCT DEVELOPMENT

Rahul Shirode* and Dr. Ashish Gorle

ABSTRACT

Granulation, it is a technique of particle enlargement by agglomeration; it is one of the most useful unit operation in the production of pharmaceutical dosage forms, mostly tablets and capsules. Although granules used in the pharmaceutical industry have particle size in the range of 200- 4000, they are primarily produced as an intermediary with a size range of 200- 500 to be either packed as a dosage form or be mixed with other excipients before tablet compaction or capsule filling. Three type of granulation techniques are mostly used in pharmaceutical industry- 1. The Direct Compression Process, 2. Dry Granulation and 3. Wet granulation. Direct compression process is used when all the ingredients can be blended and placed in a tablet compression to make a tablet without any of the ingredients having to be changed. In dry granulation process the compression of the powder blend is without the use of heat and solvent. Roller compactor (Chilsonator) is most commonly used machine to produce powder blend to slugs. It is the most desirable method of all methods of granulation. Wet granulation is a way for size enlargement which involves any process whereby small particles are agglomerated into larger, relatively permanent structures with the help of liquid binder. Several methods are used to determine the end point in wet granulation process. Like Torque vs Power, Impeller torque profile. This review is give general overview regarding granulation techniques and its advantages and limitations.

Keywords: Granulation Technology, Direct Compression Process, Dry Granulation, Roller Compactor, Wet Granulation, Torque vs Power, Impeller Torque Profile.


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