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Abstract

A REVIEW ON BUCCAL MUCOSAL ROUTE OF DRUG ADMINISTRATION

Monika Bhatt*, Ganesh Bhatt, Preeti Kothiyal and Swati Chaudhary

ABSTRACT

Oral route is the most preffered rote of drug administration. In oral route buccal mucosal rote is one of the advantageous route of drug administration. This route provides the direct access to the systemic circulation through the jugular vein bypassing the first pass hepatic metabolism which leads to high bioavailability. The drugs having low bioavailability, shorter half life and those who undergoes extensive first pass metabolism are good candidate for this rote. Various formulations have been formulated for this rote one of which is buccal film. Buccal films are prepared by using methods like solvent casting method, hot-melt extrusion method and direct milling method. Buccal films are evaluated for thickness, swelling property, surface pH, drug content, % moisture loss etc.

Keywords: first-pass metabolism, bioavailability, solvent casting, systemic circulation.


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