WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

ANTI-CANCER EFFECT OF NANO PALLADIUM-LIPOIC ACID COMPLEX FORMULATION AGAINST LUNG CANCER CELL LINE

Kanchana M*, Savitha D & Jeevitha D

ABSTRACT

The ever-increasing use of plant-derived phytochemicals and thiol rich molecules for the synthesis and stabilization of non-toxic metallic nanoparticles has gained increasing momentum for anti-cancer drug design and bioavailability. In this work, we synthesised a nanoformulation using Solanum trilobatum (SN) phytochemicals and dihydrolipoic acid (LA) for the production of palladium nanoparticles (PDNPs). The synthesized nanoparticles were analyzed by TEM. Further, this study evaluates the therapeutic efficacy of SNPDNPs and SNPD-LANPs in human lung (A549) cancer cells including cell viability comparison, cell morphology analysis and oxidative stress parameters. Accordingly, SNPD-LANPs exhibited significant cytotoxicity in A549 cells in a dose-dependent manner compared to SNPDNPs as determined by MTT and LDH analysis. SNPD-LANPs and SNPDNPs treatment also revealed significant (P<0.05) decrease in intracellular enzymatic and non enzymatic levels and increased lipid peroxidation status (TBARS) when compared to untreated A549 cells. Our result was also demonstrated a considerable alteration of apoptotic indices (nuclear morphology change stained with DAPI) as viewed through fluorescence microscope in SNPD-LANPs than SNPDNPs treated cancer cells. Taken together, the results of the present study which demonstrates that SNPD-LANPs might induce metabolic manipulation that significantly generates cell death via apoptosis and necrosis without affecting the normal cells.

Keywords:


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More