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Abstract

IN VITRO DISSOLUTION AND IN VIVO GAMMA SCINTIGRAPHIC EVALUATION OF GASTRO RETENTIVE METFORMIN TABLETS

*Manisha Karpe, Sushama Awasare, Trupti Upadhye, Yogita Pawar, Archana Damle, M. G. R. Rajan, Kisan Jadhav, Vilasroa Kadam

ABSTRACT

The aim of present study was to study the in vitro and in vivo performance of gastro retentive metformin tablet (GR-MET) formulation for its delayed release profile. The in vitro release of GRMET tablet prepared with polymeric mixture of HPMCK4M and HPMC K100M was observed.In vitro dissolution study of the GRMET was carried out using USP apparatus II and distilled water as dissolution medium and compared with in vivo gamma scintigraphy studies carried out in New Zealand rabbits. In vitro studies showed that the GR-MET released 74 % in 5 h, which matched the in vivo gastric retention half-life of 3.5 h, indicating that the designed system was retained in stomach as expected. The objective of in vivo gamma scintigraphic study was to provide a proof of concept that the floating capability of the gastro-retentive tablet was useful for increasing the gastric residence time of the dosage form. The GR-MET tablets showed significant gastro-retention at the end of 6 h.

Keywords: Gamma scintighaphy, Metformin, gastroretentive, sustained release.


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