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Abstract

DISCOVERY OF SUBSTITUTED IMIDAZO [1, 2-c] PYRIDO [3, 2-e] PYRIMIDINE BASED DERIVATIVES AS NOVEL ANTI-MICROBIAL AGENTS

K. Sudhakar Babu, V. Prabhakar*, L. K. Ravindranath, S. Shabhari Prasad, J. Latha

ABSTRACT

A Novel series of compounds were synthesised by cyclisation reaction of 2-amini nicotinic acid (1) with ammonium chloride and potassium cyanate to get pyrido [2,3-d] pyrimidine-2,4 (1H,3H) - dione (2) intermediate, which were further treated with POCl3 in presence of N, N-di methylaniline to get 2, 4-dichloropyrido [2,3-d] pyrimidine (3) derivative. Which is reacted with aqueous ammonia, reflux for 16 hrs to get compound 2-chloropyrido [2,3-d] pyrimidin-4-amine (4), which was reacted with 4-substituted phenacyl bromides (5 a-f) to get bi cyclised compounds 5-chloro-2-p-Substituted imidazo [1,2-c] pyrido [3,2-e] pyrimidines (6a-6f), which were further reacted with 4- substituted phenols (7a-b) to get Target Compounds (8a-8 l). The structures of new compounds were confirmed by IR and 1H NMR and 13C NMR spectral data. Anti-bacterial and anti-fungal activities were evaluated and compared with the standard drugs, some compounds of the series exhibited promising anti-microbial and anti-fungal activity compared to standard drugs.

Keywords: Pyrido [2, 3-d] Pyrimidines, Synthesis, Spectral data, anti-bacterial activity, antifungal activity.


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