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Abstract

SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF ENROFLOXACIN IN PURE AND DOSAGE FORMS

R. Rajapandi*, Aswathy S. R. and B. Sreedharran

ABSTRACT

Objective: A new, simple, sensitive, precise and linear two spectrophotometric methods was developed and validated for the estimation of enrofloxacin in bulk and dosage forms. Method: The developed spectrophotometric methods based on the determination of enrofloxacin by using bromothymol blue (Method-A) and Gibb’s reagent (Method-B). By using bromothymol blue, the drug forms ionpair complex with bromothymol blue (BTB) in acidic medium. These colored complexes were extracted with chloroform and maximum absorbance at 418 nm. By using Gibb’s reagent, the drug forms a colored product with Gibb’s reagent in alkaline medium (pH 9.4) at 473 nm. Results: Linearity calibration curve were obtained in a concentration range of 1.0-10 μg/mL in method A and 1.0 - 7.0 mg/mL in method-B. The results of analysis shows that the amount of drugs present in the formulation has a very good correlation with the label claim of the formulation and % RSD will be less than 2 for all the validation parameters. Recoveries studies revealed that results within the specified limits. Conclusion: The simplicity of the method was found to be satisfactory and could be used for the routine analysis of enrofloxacin in their marketed formulation.

Keywords: Bromothymol blue, Enrofloxacin, Gibb’s reagent and Method development.


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