WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

PREPARATION AND EVALUATION OF FLOATING TABLET OF METFORMIN HCL

Rehana Parveen* and Ranjeet Kumar Bhargav

ABSTRACT

The objective of the research work was to provide a gastroretentive system for sustained release of metformin HCl in proximal part gastrointestinal tract (GIT) in the form of oral floating tablet. Metformin HCl is an anti-diabetic biguanid with poor bioavailability and absorption window at the upper part of GIT. Floating tablets were prepared by wet granulation method incorporating natural polymers guar gum and k-Carrageen and a synthetic polymer HPMC K100 (HPMC) either alone or in combination. Sodium bicarbonate and citric acid was used as gas generating agent. Floating tablets were evaluated for weight variation, hardness, and friability, drug content, swelling index, in vitro buoyancy and in vitro drug release study. The formulation optimized based on floating ability, matrix integrity, and in vitro drug release in simulated gastric fluid pH 1.2. Formulation prepared with combination of 6% w/w k-carrageen and 11%w/w guar gum showed good gel strength, stable and persistent buoyancy for 12h, least floating lag time of 58 sec with good matrix integrity throughout dissolution period. The mechanism of drug release was appears to be diffusion mechanism. Stability studies indicated absence of any drug degradation on storage for 3 months at 40oC.

Keywords: Floating, Buoyancy, Gastro retentative, Sustained Release.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More